@article{MAKHILLJEAS201813615835,
    title = {<I>In Vitro</I> Antiproliferative Effect, Cytotoxicity and Apoptosis Study of Biogenic
Silver Nanoparticles Synthesized Using <i>Sterculia quadrifida</i> leaf Extract},
    journal = {Journal of Engineering and Applied Sciences},
    volume = {13},
    number = {6},
    pages = {1414-1420},
    year = {2018},
    issn = {1816-949x},
    doi = {jeasci.2018.1414.1420},
    url = {https://makhillpublications.co/view-article.php?issn=1816-949x&doi=jeasci.2018.1414.1420},
    author = {Vishnu},
    keywords = {Sterculia quadrifida,AgNPs,UV-vis-spectroscopy,AFM,TEM,antiproliferative,cytotoxicity},
    abstract = {Bio-nano synthesis and its widespread applications have become essential for sustainable
development and welfare of humanity. The present study reports a biosynthetic pathway to produce highly
stable, bio-inspired silver Nanoparticles (AgNPs) using fresh Sterculia quadrifida leaves. Following the
traditional approach, UV-visible spectroscopy confirmed the formation of AgNPs. AFM and TEM
results revealed their size, morphology and crystalline nature. Moreover, FTIR analysis exposed the
nature of biomolecules adhering to the surface of silver nanoparticles which increased their stability.
Sterculia quadrifida extracts rendered excellent reducing capability. Consequently, this procedure proved to
be simpler, eco-friendly, cost-effective, reproducible and compatible with medical and pharmaceutical
applications as well as large-scale commercial production. The nanoparticles, thus, synthesized, exhibited
effective antimicrobial activity and AgNPs together with phytochemicals resulted in a strong antiproliferative
effect. As such MTT assay helped to determine the levels of cytotoxicity. Furthermore, the study of apoptosis
elucidated the possibility of employing AgNPs for programmed cell death. Since, increased apoptosis is a
characteristic feature of AIDS, Alzheimer&#146;s and Parkinson&#146;s disease and decreased apoptosis trigger lupus or
cancer, AgNPs can induce apoptosis in such cancer or tumor cells.}
    }