@article{MAKHILLJEAS202015118878,
    title = {Efficiency Improvement of a Gas Chromatographic-Mass Spectrometric Method for
Quantification of Nicotine in Hookah (Water Pipe) Tobacco Products},
    journal = {Journal of Engineering and Applied Sciences},
    volume = {15},
    number = {1},
    pages = {220-226},
    year = {2020},
    issn = {1816-949x},
    doi = {jeasci.2020.220.226},
    url = {https://makhillpublications.co/view-article.php?issn=1816-949x&doi=jeasci.2020.220.226},
    author = {Hazim},
    keywords = {Hookah tobacco products,nicotine,methyl nicotinate,single-step extraction procedure,sensitivity,recovery},
    abstract = {In the present study, a highly sensitive Gas Chromatographic-Mass Spectrometric (GC-MS) method
and single-step extraction procedure have been developed for the determination of nicotine level in Hookah
tobacco products samples. The principle focus of the developed method is the lower limit of detection
(0.025 ng mL<sup>&#150;1</sup>) and a wide linear range (0.03-17000 ng mL<sup>&#150;1</sup>) achieved that can have important implications
in the determination of nicotine in any investigated samples. In addition, the accuracy and precision values of
the method were in the range of 98.07-103.81 and 0.2660-1.7712%, respectively. While the extraction recovery
of nicotine, when spiked to hookah tobacco products was ranged from 94.85-98.00%. The present
chromatographic method showed higher sensitivity, linearity precision and accuracy, when compared with the
reported chromatographic methods. Finally, the hookah tobacco products samples were used to evaluate the
method applicability for the determination of nicotine.}
    }