@article{MAKHILLRJANS20148327727,
    title = {Evaluation of Prophylactic Cloprostenol and <I>E. coli</I> LPS Treatment Against Endometritis in Dairy Cows and Buffaloes},
    journal = {Research Journal of Animal Sciences},
    volume = {8},
    number = {3},
    pages = {24-29},
    year = {2014},
    issn = {1993-5269},
    doi = {rjnasci.2014.24.29},
    url = {https://makhillpublications.co/view-article.php?issn=1993-5269&doi=rjnasci.2014.24.29},
    author = {B.U.,P.S.,S. and},
    keywords = {Buffaloes,cows,cloprostenol,E. coli LPS,endometritis,reproductive performance},
    abstract = {A field trial was conducted to evaluate immunomodulatory prophylactic modalities against persistent uterine infection in 24 Murrah buffaloes and 21 cross-bred Holstein Frisian cows. All animals were treated with intramuscular ceftiofur sodium for 5 days post-calving. On or after 7th day animals were randomly assigned to either; intrauterine normal saline (controls = 15), intrauterine <I>E. coli</I> LPS (LPS = 15) or intramuscular Cloprostenol (cloprostenol = 15). Endometritis was Determined at 35 days in Milk (DIM) and estrus, breeding and conception were monitored until 120 DIM. Clinical Endometritis (CE) occurred in 6 (60%), 3 (30%) and 2 (20%) assisted calving animals assigned to control, cloprostenol and LPS groups, respectively (p = 0.196). All but one assisted calving animals had cytological uterine inflammation at 35 DIM. Among normal calving animals 1 (20%), 3 (60%) and 4 (80%) of those in control, LPS and cloprostenol groups, respectively showed cytological uterine inflammation (p = 0.415). Meanwhile, 93.3, 86.7 and 66.7% of the LPS, Cloprostenol and Control group animals were observed in heat within 120 DIM (p = 0.229). Rate of conception within 120 DIM was similar 3 (37.5) among treatment groups in buffaloes but varied in cows from a high of 3 (42.9) in control group to a low of 0 in Cloprostenol group. The application of early puerperal immunostimulatory treatment with cloprotenol or <I>E. coli</I> LPS for prevention of endometritis and sub-fertility appears limited requires further validation.}
    }