TY  - JOUR
T1  - Pancreatic Weakness in Zucker Fatty Rats, a Genetic Obese Model
AU - Ohta, Takeshi AU - Miyajima, Katsuhiro AU - Yamada, Takahisa 
JO  - Journal of Animal and Veterinary Advances
VL  - 9
IS  - 23
SP  - 2963
EP  - 2968
PY  - 2010
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2010.2963.2968
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2010.2963.2968
KW  - Diabetes
KW  -pancreas
KW  -streptozotocin
KW  -ZF rat
KW  -dysfunction
KW  -weakness
AB  - Pancreatic dysfunction is a pivotal factor on incidence and development of diabetes mellitus and especially, the pancreatic weakness is a key defect contributing to diabetes mellitus. In this study, we investigated the pancreatic weakness in obese Zucker Fatty (ZF) rats. Different doses of Streptozotocin (STZ) were administered to ZF rats and the biochemical and the pancreatic related parameters were examined. Wistar rats were used as control animals. Before STZ injection, ZF rats showed a tendency to increase of insulinogenic index as compared with that in Wistar rats but the disposition index in ZF rats was significantly decreased as compared with that in Wistar rats. Moreover, the islets of STZ-untreated ZF rats were larger and had irregular boundaries. ZF rats treated with STZ at a dose level of 20 mg kg<SUP>-1</SUP> were diabetic within one week after the treatment whereas Wistar rats got the diabetic after 30 mg kg<SUP>-1</SUP> STZ was received.
ER  -