TY  - JOUR
T1  - Matrix Metalloproteinase Expression in a Mouse Menstrual-Like Model by Pharmacologic Progesterone Withdrawal
AU - Xu, Xiangbo AU - Chen, Xihua AU - Wang, Jiedong AU - He, Bin 
JO  - Journal of Animal and Veterinary Advances
VL  - 12
IS  - 13
SP  - 1139
EP  - 1146
PY  - 2013
DA  - 2001/08/19
SN  - 1680-5593
DO  - javaa.2013.1139.1146
UR  - https://makhillpublications.co/view-article.php?doi=javaa.2013.1139.1146
KW  - Mouse
KW  -pharmacological withdrawal of progesterone
KW  -menstruation
KW  -matrix metalloproteinase
KW  -regional distribution
AB  - MMPs are vital in menstruation. This study aimed to investigate 
  their expressions in a mouse menstrual-like model by pharmacologic progesterone 
  withdrawal. The model was prepared by administration of mifepristone after decidualization 
  of ovariectomized mice. Immunohistochemistry was performed to detect the locations 
  of Matrix Metalloproteinase (MMPs) proteins. MMP3 was present in the focal subluminal 
  stromal zone, epithelium, decidual zone and interface between the basal zone 
  and functional zone from 0-24 h and epithelium and subluminal epithelium stroma 
  from 32-48 h. MMP7 was present in the basal zone, epithelium and mid decidual 
  zone from 0-24 h and a similar location to MMP3 from 32-48 h. MMP9 was present 
  in the basal zone and focal zone of the subluminal stroma from 0-24 h, epithelium 
  and the edge of tissue breakdown at 32 h, basal zone and the subluminal stroma 
  at 40 h and the subluminal stroma at 48 h. MMP13 was present in the mid decidual 
  zone at 24 and 32 h and epithelium at 40 and 48 h. MMP2 was present in the basal 
  zone and mid decidual zone from 0-24 h, the mid decidual zone at 32 h and no 
  staining at 40 and 48 h. The locations of MMPs protein in the model displayed 
  regional character and showed consistency with those in the mice model by physiological 
  progesterone withdrawal and in primates.
ER  -