TY  - JOUR
T1  - Assessment of Changes in Anxiety and Exploratory Behaviors Following Zinc Supplementation in Rats
AU - , Saeid Sobhanirad AU - , Reza Valizadeh AU - , Ali Moghimi AU - , Abdolmansoor Tahmasebi 
JO  - Research Journal of Biological Sciences
VL  - 3
IS  - 12
SP  - 1415
EP  - 1418
PY  - 2008
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2008.1415.1418
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2008.1415.1418
KW  - Anxiety behavior
KW  -exploratory behavior
KW  -open-field
KW  -supplemental zinc
KW  -rat
AB  - In an experiment the emotional and exploratory behaviors of Wistar rats to dietary zinc supplementation from zinc sulfate monohydrate (ZnS), Zinc oxide (ZnO) and zinc Methionine (ZnM) were studied  in  an  open  field test. One hundred-twenty rats were assigned to 10 dietary treatments including: Basal Diet (BD) + 50 mg kg<SUP>-1</SUP> ZnS, BD + 100 mg kg<SUP>-1</SUP> ZnS, BD + 200 mg kg<SUP>-1</SUP> ZnS, BD + 50 mg kg<SUP>-1</SUP> ZnO, BD + 100 mg kg<SUP>-1</SUP> ZnO, BD + 200 mg kg<SUP>-1</SUP> ZnO, BD + 50 mg kg<SUP>-1</SUP> ZnM, BD + 100  mg kg<SUP>-1</SUP>  ZnM,   BD + 200 mg kg<SUP>-1</SUP> ZnM and Basal diet (without Zn supplementation). These parameters including rearing, number of peripheral squares crossing, number of central squares crossing, hole exploration and defecation were recorded for 5 min. The treatments differed significantly in case of hole exploration and defecation. The results of these experiments indicated that high level of zinc methionine (200 mg kg<SUP>-1</SUP>) increased exploratory activity and locomotor activity. The results of this experiment indicated that high  level  of  zinc  methionine  (200 mg kg<SUP>-1</SUP>) reduced exploratory activity and anxiety-like behavior. Further studies are needed to identify the anxiolytic mechanism and the optimum level of Zn supplementation.
ER  -