TY  - JOUR
T1  - Maternal Serum Screening for Down Syndrome: Effect of Different Set of Distribution Parameters on Efficacy and Reliability of System
AU - Amini, Rana AU - Yahyazade, Hamed AU - Rahbar, Mohammad 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 5
SP  - 395
EP  - 399
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.395.399
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.395.399
KW  - distribution parameters
KW  -prenatal diagnosis
KW  -Serum screening protocols
KW  -Down syndrome
KW  -MSAFP
KW  -Iran
AB  - The researchers tried to use the result of multiple markers assays in maternal serum to establish a mathematical method for calculating the risk of carrying a fetus with Down syndrome. This screening method is dependent on distribution of few parameters. We investigated the effect of different set of parameters on screening system. The most popular protocol for triple marker screening of Down syndrome is based on multivariate gaussian distribution. This study has been applied in a private medical laboratory. The result of different set of distribution of parameters on efficacy and reliability of system is investigated by graphical display and simulation by monte carlo method. In some cases, different sets of parameters in protocols make calculated risk inappropriately different. In some ranges of biochemical markers, the behavior of system violates their general trends on risk calculation. We found inherent error in models. This could be explained by interaction and value of distribution of parameters. We show effect of distribution of parameters in mathematical model, estimate efficacy of system and also emphasize on quality of parameters.
ER  -