TY - JOUR
T1 - TNF-α and IL-10 Levels: Possible Risk Markers For Latent M. tuberculosis
Infections Among Sudanese
AU - Yousef, B.A. AU - Khalil, E.A. AU - Hamid, N.H. AU - Widatalla, S.E.
JO - International Journal of Tropical Medicine
VL - 9
IS - 1
SP - 1
EP - 6
PY - 2014
DA - 2001/08/19
SN - 1816-3319
DO - ijtmed.2014.1.6
UR - https://makhillpublications.co/view-article.php?doi=ijtmed.2014.1.6
KW - TNF-a and IL-10
KW -whole blood assay
KW -pulmonary tuberculosis
KW -latent tuberculosis
KW -TB patients
AB - Factors responsible for the control of M. tuberculosis
infection includes T cells, macrophages and cytokines. The incidence and prevalence
of latent tuberculosis in Sudan have not yet been reported and latent tuberculosis
infection is regarded as a significant risk factor for active pulmonary tuberculosis.
This study aimed to understand the role of immune responses particularly the
cytokines profile (levels of TNF-α and IL-10) as risk factors of infection
in patients with active and latent M. tuberculosis infections. A case
control study was conducted in various hospitals in Greater Khartoum, a total
of 48 patients and volunteers were enrolled (17 active pulmonary TB patients,
17 latent TB patients and 14 apparently healthy individuals). Whole blood culture
with PPD, PHA and LPS stimulation and TNF-α and IL-10, measurement by ELISA
were conducted. The results have shown TNF-α and IL-10 significantly higher
in active TB patients compared to latent TB patients and healthy individuals
(p<0.001). On the other hand, patients with latent TB infection had significantly
higher levels of TNF-α and IL-10 compared to healthy individuals (p<0.001).
Therefore, the differences in the TNF-α and IL-10 levels probably indicate
pivotal roles in the pathogenesis of M. tuberculosis infection. Furthermore,
TNF-α and IL-10 levels can provide a useful risk marker for the development
of overt and latent TB infections.
ER -