TY - JOUR
T1 - The Effectiveness of the Flesh of Durian (Durio zibethinus) in Increasing Platelet Count on
Balb/C Mice (Mus musculus): A Prospective Study
AU - A. Atienza, Beaven Andrew AU - Catherine S. Abarca, Sylver AU - B. Basir, Norhana AU - B. Hassan, Damra AU - Mari P. Shariff, Czarina
JO - International Journal of Tropical Medicine
VL - 15
IS - 2
SP - 36
EP - 38
PY - 2020
DA - 2001/08/19
SN - 1816-3319
DO - ijtmed.2020.36.38
UR - https://makhillpublications.co/view-article.php?doi=ijtmed.2020.36.38
KW - Balb/C mice
KW -flesh of durian
KW -platelet count
KW -administration
KW -treatment
AB - This study aimed to determine the effectiveness
of durian in increasing the platelet count of white mice.
Pre and post-test design was used. Subjects were
conditioned and randomly selected: 5 Balb/C mice each
for group. Initial platelet count was done three days
before administration of 1 mL blended durian on
experimental group. The control group not administered
was fed with the same pellet and water daily. After three
consecutive days final platelet counts were obtained.
Results showed notable increase in the platelet count from
187.000 (initial count) to 311.600 (final count) on Balb/C
mice after ingesting durian flesh. The initial mean platelet
count of mice before administration of the durian
preparation is iE = 187.200×10 g L–1. After 3 consecutive
days of treatment, it significantly increased from
fE = 187.200×10 g L–1 to iE = 311.600×10 g L–1. With a
difference of iE-fE = 124.400×10 g L–1 in the platelet
reading, this represents the effectiveness of the Balb/C
mice in increasing platelet count. This remarkable result
goes to show that durian flesh is effective in increasing
platelet count of mice. For future researchers, it is
recommended that there is a need of increase in terms of
dosage, days of administration, the number of test
subjects, the use of other varieties of durian and as well as
the other parts of durian fruit for effectiveness in the
increase of platelet count[1].
ER -