TY  - JOUR
T1  - Accurate Estimation of Blood Glucose with HbA<SUB>1C</SUB> Quantification by a Reliable Photo Acoustic Method
AU - , J. Sundararajan AU - , V. Palanisamy AU - , Mandyam Sandeep 
JO  - Journal of Engineering and Applied Sciences
VL  - 3
IS  - 1
SP  - 85
EP  - 93
PY  - 2008
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2008.85.93
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2008.85.93
KW  - Photo Acoustic HbA1C (PAH)
KW  -stable ketoamine adduct
KW  -pulsed laser diode
KW  -photo acoustic signal strength
AB  - Diabetes Mellitus, a disorder that results in abnormality of blood glucose levels, has been the rapidly growing disorder currently reported. Glucose, being one of the most important compound that in vital for the human body, should be maintained in correct levels. The right blood glucose level is important as it provides different parts of the body with energy to function properly. Diabetics must hence know their blood glucose levels, so that they can control them with supplements like oral drugs, other treatments or calisthenics. The measurement of the total glucose concentration is currently invasive and time consuming. The most popular method of glucose quantification is to estimate the glycated hemoglobin concentration. The glucose measurements are accurate in this method the reason being that the hemoglobin molecules pick up glucose in about the same proportion as the glucose that exists in the bloodstream. The photo acoustic technique of HbA<SUB>1C</SUB> may provide accurate and non-invasive measurement of glycated hemoglobin concentration by probing blood vessels that in turn gives the total blood glucose concentration. In this research, we studied the influence of photo acoustic signals on the HbA<SUB>1C</SUB>, an important constituent of the RBC (stable ketoamine adduct) and illustrate the results to compute the blood glucose levels. The results obtained by this method prove to be strikingly similar (highly efficient) compared to the standard <I>in-vitro</I> procedures. Further extension of this technique can be made to study the other blood components.
ER  -