TY  - JOUR
T1  - Evaluation of ZnuA (Zinc-Binding Protein) Linear and Conformational Epitopes in <i>Propionibacterium acnes</i>
AU - Nahal, Fateme Sharaf AU - Sefid, Fateme AU - Kalantari, Golnaz AU - Naderi, Faeze Shafi AU - Khosravi, Mahsa AU - Dahaj, Fourozan Esmaili AU - Ashkani, Haniye 
JO  - Journal of Engineering and Applied Sciences
VL  - 12
IS  - 5
SP  - 1212
EP  - 1217
PY  - 2017
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2017.1212.1217
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2017.1212.1217
KW  - Propionibacterium
KW  -ZnuA
KW  -linear and conformational epitopes
KW  -bioinformatic
KW  -Iran
AB  - <i>Actinobacillus pleuropneumoniae</i> is the causative agent of acute and chronic pleuroneumonia that is responsible for substantial morbidity and mortality in the pig industry. New improved vaccines that can protect against all serotypes and prevent colonization are required. Previous studies showed that whole cells of <i>Propionibacterium acnes</i> protected pigs from <i>A. pleuropneumoniae</i> serotype 1 and 5 and therefore the basis for a promising heterologous vaccine. The aim of this study was to identify those protein antigens of P. acnes responsible for protection against <i>A. pleuropneumoniae</i> infection. Antibodies that are induced by recombinant PASsb cross-react with epitopes in the ApxIV and ZnuA proteins of <i>A. pleuropneumoniae</i>. ZnuA is a known <i>A. pleuropneumoniae</i> immunogenic protein and is required for virulence.
ER  -