TY  - JOUR
T1  - <I>In Vitro</I> Antiproliferative Effect, Cytotoxicity and Apoptosis Study of Biogenic
Silver Nanoparticles Synthesized Using <i>Sterculia quadrifida</i> leaf Extract
AU - Rajendran, Vishnu 
JO  - Journal of Engineering and Applied Sciences
VL  - 13
IS  - 6
SP  - 1414
EP  - 1420
PY  - 2018
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2018.1414.1420
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2018.1414.1420
KW  - Sterculia quadrifida
KW  -AgNPs
KW  -UV-vis-spectroscopy
KW  -AFM
KW  -TEM
KW  -antiproliferative
KW  -cytotoxicity
AB  - Bio-nano synthesis and its widespread applications have become essential for sustainable
development and welfare of humanity. The present study reports a biosynthetic pathway to produce highly
stable, bio-inspired silver Nanoparticles (AgNPs) using fresh Sterculia quadrifida leaves. Following the
traditional approach, UV-visible spectroscopy confirmed the formation of AgNPs. AFM and TEM
results revealed their size, morphology and crystalline nature. Moreover, FTIR analysis exposed the
nature of biomolecules adhering to the surface of silver nanoparticles which increased their stability.
Sterculia quadrifida extracts rendered excellent reducing capability. Consequently, this procedure proved to
be simpler, eco-friendly, cost-effective, reproducible and compatible with medical and pharmaceutical
applications as well as large-scale commercial production. The nanoparticles, thus, synthesized, exhibited
effective antimicrobial activity and AgNPs together with phytochemicals resulted in a strong antiproliferative
effect. As such MTT assay helped to determine the levels of cytotoxicity. Furthermore, the study of apoptosis
elucidated the possibility of employing AgNPs for programmed cell death. Since, increased apoptosis is a
characteristic feature of AIDS, Alzheimer&#146;s and Parkinson&#146;s disease and decreased apoptosis trigger lupus or
cancer, AgNPs can induce apoptosis in such cancer or tumor cells.
ER  -