TY  - JOUR
T1  - Preparation, Investigation and Enzymatic Activity of Mixed Iigand Complexes of
Mefenamic Acid and Phenyl Alanine with some Transition Metal
AU - Khamis, Wessal M. AU - Abbas, Bayader F. AU - Abdulsada, Shaemaa Hadi AU - Mohammed, Mustafa Taha AU - Sultan, Alaa A. AU - Khamis, Nedhal M. 
JO  - Journal of Engineering and Applied Sciences
VL  - 14
IS  - 3
SP  - 734
EP  - 743
PY  - 2019
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2019.734.743
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2019.734.743
KW  - Mefenamic acid
KW  -phenyl alanine
KW  -enzymatic study of metal complexes
KW  -MAO
KW  -AChE
KW  -human serum
AB  - This research contain preparation of transitions metal complexes for metals (Mn<sup>+2</sup>, Co<sup>+2</sup>, Ni<sup>+2</sup>, Cu<sup>+2</sup>)
with the mixed ligands of mefenamic acid and L-phenylalanine. The prepared complexes were investigated by
using spectra methods of FTIR, UV-visible spectroscopy, molar conductivity, suspicibility magnetic
measurements as well as melting points. Stereo chemistry of complexes were accomplished which showed that
geometry of mixed ligand Mef:M:Phenyl alanine with (Mn<sup>+2</sup>, Ni<sup>+2</sup>, Cu<sup>+2</sup>) metal which have the molecular formula
(513, 516.7, 521.5), respectively. Cobalt complex only has the distorted octahedral with molecular formula (588).
Enzymatic activity study for prepared Ni<sup>+2</sup>, Cu<sup>+2</sup> complexes were calculated the possibility of activation and
reactivation (for previously inhibited enzymes) deactivation of enzymes AChE. MAO at human serum. These
complexes showed ability for activation or reactivation of enzymes activity at human serum. Metal complexes
of (Ni<sup>+2</sup>, Cu<sup>+2</sup>) were deactivated the enzymatic reaction. The order reaction of enzymatic reaction were achieved
and it were first order reaction for (Ni<sup>+2</sup>,Cu<sup>+2</sup>) complexes as inhibitors for enzymatic reaction. K<sub>m</sub> and V<sub>max</sub> were calculated for the tow reactions.
ER  -