Yong-Xue  Sun, Hai-Yan  Zhao, Yu-Jing  Liu, Zhen-Qing  Dai, Bing-Hu  Fang, 
    Toxicokinetics of T-2 Toxin, HT-2 Toxin and T-2 Triol after Intravenously Administrated T-2 Toxin in Swine,
    Journal of Animal and Veterinary Advances,
    Volume 11,Issue 12,
    2012,
    Pages 1977-1981,
    ISSN 1680-5593,
    javaa.2012.1977.1981,
    (https://makhillpublications.co/view-article.php?doi=javaa.2012.1977.1981)
    Abstract: Toxicokinetics of trichothecene mycotoxin, T-2 toxin, HT-2 toxin and T-2 triol were determined in seven swine, after intravenous administration (i.v.) of T-2 toxin (0.5 mg kg<SUP>-1</SUP>). The T-2 toxin, HT-2 toxin and T-2 triol plasma concentrations were analyzed by HLPC-MS/MS from 2.5 min to 6 h. The mean pharmacokinetic parameters for T-2 toxin, HT-2 toxin and T-2 triol were respectively: half-life (t<SUB>1/2&#955;Z</SUB>) 11.7, 37.7 and 25.6 min; areas under the plasma concentration-time curves (AUC<SUB>0-00</SUB>): 16499, 4619 and 11011 min ng mL<SUP>-1</SUP>. Following i.v administration, times to observed maximal concentration (Tmax) were 2.5, 2.5 and 7.5 min, respectively. No T-2 tetraol was detected at all sampling times. The total body Clearance (Cl) and the apparent steady-state volumes of distribution (V<SUB>ss</SUB>) for T-2 toxin were 0.662 L kg<SUP>-1</SUP> and 0.038 L/min/kg. This study demonstrated that T-2 toxin is rapidly removed from the blood followed by its fast conversion to metabolites.
    Keywords: Toxicokinetics;T-2 toxin;metabolites;swine;blood;parameters