Siti  Sunarintyas, Widowati  Siswomihardjo, Jukka  Pekka Matinlinna, 
    Biological Property of HDDMA Based Resin Matrix System for Dentistry,
    Journal of Engineering and Applied Sciences,
    Volume 11,Issue 12,
    2016,
    Pages 2673-2677,
    ISSN 1816-949x,
    jeasci.2016.2673.2677,
    (https://makhillpublications.co/view-article.php?doi=jeasci.2016.2673.2677)
    Abstract: Recently, there is a great interest in the replacement of commercial bis-GMA resin matrix system for
dentistry. Bis-GMA is considered to be relatively cytotoxic and allergenic to human. A novel resin matrix
system based on HDDMA is under investigation. This study aimed to determine the biological property
especially the cytotoxicity property of proposed HDDMA-based resin matrix systems of FRCs material toward
fibroblast cells. Fifteen FRCs specimens were prepared and divided into 3 groups. Two groups were based on
HDDMA matrix systems and one group was bis-GMA-based. The cytotoxicity property was determined by
MTT method. The result revealed significant differences in cells viability between HDDMA-based matrices and
bis-GMA-based, whilst no significant difference between the two proposed HDDMA-based matrices. In
conclusion, proposed resin matrix systems based on HDDMA exhibited a less cytotoxic material than bis-GMAbased.
    Keywords: HDDMA;bis-GMA;cytotoxicity;cells;FRCs