Ka-Eun  Kim, Chung-Poong  Hwang, Soon-Kwon  Park, Il-Young  Cho, 
    Effect of MAD (Mandibular Advancement Device) on
Obstructive Sleep Apnea and Quality of Sleep,
    Journal of Engineering and Applied Sciences,
    Volume 12,Issue 14,
    2017,
    Pages 3616-3621,
    ISSN 1816-949x,
    jeasci.2017.3616.3621,
    (https://makhillpublications.co/view-article.php?doi=jeasci.2017.3616.3621)
    Abstract: This study is intended to verify the efficacy of oral airway dilatation using MAD for the treatment
of sleep apnea and quality of sleep compare to surgical treatment. The study performed an obstructive sleep
apnea evaluation (polysomnography, endoscopy, degree of tonsillar hypertrophy, sleep apnea-related
questionnaires and radiation inspection) with patients visiting sleep centers or otorhinolaryngology of three
medical institutions due to sleep apnea. A total of 62 hospitalized patients with a chief complaint of snoring or
sleep apnea were recruited. The 3 participants could not complete the study and dropped out; the 59
participants completed the study as planned. In the primary analysis of efficacy evaluation, the difference
between the findings at baseline and visit 5 and the analysis for each medical institution were analyzed for AHI,
PSQI, ESS and SaO<sub>2</sub> . The mean AHI, indicating level of sleep apnea, at week 5 after treatment decreased. For 
PSQI for measuring the sleep quality, the measured value at visit 5 after treatment was increase. For ESS for
measuring daytime sleepiness, the value also decreased. SaO<sub>2</sub> during sleep also increased and all of these 
results were statistically significant. In the secondary analysis of comparison of success rate there was no
statistical difference between the success rate of airway dilation using MAD and the success rate of UPPP. The
difference in the success rates among the medical institutions was also not statistically significant. These
findings indicate that this product has the comparative advantage to the surgery in terms of less complications
and the low cost.
    Keywords: MAD;obstructive sleep apnea;quality of sleep;medical institutions;complications