Saharman  Gea, Khatarina  Meldawati Pasaribu, Tamrin  Tamrin, Syafruddin  Ilyas, 
    Fabricated Bacterial Cellulose-Based Composites for Skin Tissue Engineering,
    Journal of Engineering and Applied Sciences,
    Volume 15,Issue 7,
    2020,
    Pages 1640-1644,
    ISSN 1816-949x,
    jeasci.2020.1640.1644,
    (https://makhillpublications.co/view-article.php?doi=jeasci.2020.1640.1644)
    Abstract: Bacterial Cellulose (BC) has the ability as tissue scaffolding, since, this material has excellence
properties including high water holding capacity, high crystallinity as well as elasticity. This research focused
on investigating the fabrication of bacterial cellulose-based compisites for skin tissue engineering. BC was
produced via agitated culture medium while its adding with chitosan and collagen were obtained through ex-situ
method which was done by immersing BC pellicles to chitosan or collagen solution for 24 h. Based on the
Thermal Gravimetric Analysis (TGA), the scaffold material BC-Chitosan-Collagen gave a rising value of
temperature which was 35.43°C for 1% mass loss, implying the improvement of thermal properties of materials.
From Differential Thermal Analysis (DTGA), it is recorded that T<sub>max</sub> of BC-collagen is 330&deg;C. Scanning
Electron Microscope (SEM) shows that the presence of chitosan and collagen into BC fibers resulted
in a well-interconnected network structure. These results imply that BC-based composites with collagen or
chitosan can serve for skin tissue engineering.
    Keywords: ex-situ;composite;collagen;BC;chitosan