Putut  H. Riyadi, Yudhomenggolo  S. Darmanto, Apri  D. Anggo, Vivi  E. Herawati, Retno  A. Kurniasih, 
    Potential of Hydrolyzed Waste in <i>Portunus sp.</i> Non-Shell as Nutraceutical with Bioinformatics
Analysis,
    Journal of Engineering and Applied Sciences,
    Volume 15,Issue 10,
    2020,
    Pages 2327-2331,
    ISSN 1816-949x,
    jeasci.2020.2327.2331,
    (https://makhillpublications.co/view-article.php?doi=jeasci.2020.2327.2331)
    Abstract: This study aims to obtain a profile of the
potential hydrolyzate of Portunus sp. with bioinformatics
analysis. The material used in this study was Portunus sp.
non-shell from the meat canning industry Portunus sp.
Non-shell waste is hydrolyzed using papain enzyme to
produce hydrolyzate. The hydrolyzate was screened with
LC-HRMS and analyzed using swiss ADME, PASS and
Pro Tox. LC-HRMS screening shows the results that there
are twelve compounds, namely L-Phenylalanine,
Tryptophan, trans-3-Indoleacrylic acid, Isoleucine,
Betaine, Trigonelline, Adenosine, Tyrosine,
Propionylcarnitine, Stachydrine, Maltose, Arginine. swiss
ADME analysis shows that the hydrolyzate of Portunus
sp. has potential as a pretty good drug ingredient based on
the review of Lipinski&#146;s rules and pharmacokinetic
property. The results of the PASS analysis to predict the
potential for biological activity indicate that the
hydrolyzate of Portunus sp. Non-shell has potential as
NADPH peroxidase inhibitors, Omptin inhibitors,
Membrane integrity agonists, Preneoplastic conditions
treatment, Phobic disorders treatment, Antiseborrheic,
Pseudolysin inhibitors, Saccharopepsin inhibitors.
Toxicity analysis based on Pro Tox predictions showed no
potential Carcinogenicity, Immunotoxiticity,
Mutagenicity. These results indicate that the hydrolyzate
of <i>Portunus sp</i>. potentially as a nutraceutical and safe for
consumption.
    Keywords: Hydrolyzate;Portunus sp.;non-shell waste;nutraceutical;bioinformatics