@article{MAKHILLRJBS201161211304, title = {Evaluation of Anti-Fungal Activity of Synthesized Chalcone Semicarbazone Derivatives}, journal = {Research Journal of Biological Sciences}, volume = {6}, number = {12}, pages = {632-634}, year = {2011}, issn = {1815-8846}, doi = {rjbsci.2011.632.634}, url = {https://makhillpublications.co/view-article.php?issn=1815-8846&doi=rjbsci.2011.632.634}, author = {Manmohan and}, keywords = {Anti-fungal,semicarbazones,chalcone,disk diffusion,lipophilic site,India}, abstract = {In the present study, researchers designed a Pharmacophore Model chalconesemicarbazone which is having hydrogen acceptor site, hydrogen donor site, lipophilic site, etc., using Ligandscout-2.02 software. A series of chalcone semicarbazones was synthesized and evaluated for their anti-fungal activity by Paper Disk Diffusion Method. Based on the results of an anti-fungal study, compound CS-10 was the most active compound. It was observed that methoxy substitution in aldehydic moiety and hydroxyl substitution in the acetophenic moiety significantly increased anti-microbial spectrum against fungi.} }