TY  - JOUR
T1  - Contextual Developmental History of Evolving Global and Focal Parameters in Multiple Sclerosis Progression
AU - Agius, Lawrence M. 
JO  - International Journal of Molecular Medicine and Advance Sciences
VL  - 5
IS  - 1
SP  - 1
EP  - 5
PY  - 2009
DA  - 2001/08/19
SN  - 1813-176x
DO  - ijmmas.2009.1.5
UR  - https://makhillpublications.co/view-article.php?doi=ijmmas.2009.1.5
KW  - Inflammation
KW  -multiple sclerosis
KW  -plaque
KW  -demyelination
KW  -blood-brain barrier
AB  - Dimensional confines of the individual demyelinating plaque in multiple sclerosis indicate a focal or multifocal involvement of the parent axon and also a global progressiveness of the involvement of the blood-brain barrier. A gliopathy affecting viability of the astrocytic foot processes may be re-interpreted within constructs of involvement by a depleted oligodendroglial cell compartment within the demyelinating plaque. It is particularly significant to view dynamics of remyelination within a contextual setting of an afflicted parent axon. Progressiveness is hence compounded by multiple constructs in development of a lesion that is physico-chemically related to new foci of involvement of grey and white matter, beyond the confines of established plaque pathology. In this sense, therefore, a conventional role for a presumed viral etiology would insufficiently account for a multi-focal involvement that mirrors the global dimensions of the blood-brain barrier defects.
ER  -