TY  - JOUR
T1  - Neonatal Late-Onset Sepsis in a NICU: Analysis of Causative Organisms and Antimicrobial Susceptibility Ali Asghar Children Hospital from (2004/5-2007/5), Tehran, Iran
AU - Asghart, Marzban AU - Samaee, Hadi AU - Hossein, Pourmemari Mohamad AU - Amir, Vahedian Azimi 
JO  - Research Journal of Biological Sciences
VL  - 5
IS  - 5
SP  - 376
EP  - 379
PY  - 2010
DA  - 2001/08/19
SN  - 1815-8846
DO  - rjbsci.2010.376.379
UR  - https://makhillpublications.co/view-article.php?doi=rjbsci.2010.376.379
KW  - Late-onset sepsis
KW  -antibiogram
KW  -neonate
KW  -bacteremia
KW  -nosocomial
KW  -Iran
AB  - Bacterial sepsis is one of the most common causes of significant mortality and morbidity in neonates. The researchers analyzed bacterial isolates and their antibiotic susceptibilities for cases of septicemia in a Neonatal Intensive Care Unit (NICU) of a teaching hospital in Tehran, Iran. During a 36 months period, the incidence of bacteremia and the causing organisms and mortality of sepsis as well as antibiotic susceptibility were investigated. Neonatal Late-Onset Sepsis (LOS) was defined as clinical signs suggestive of infection with a positive Blood Culture (B/C) after 72 h of birth. About 909 neonates were admitted to the NICU. A total of 9.13% of neonates (83/909) had at least one positive B/C after 72 h of birth. The vast majority (56.6%) of sepsis were caused by Gram-negative organism. Gram-positive pathogens accounted for 41% infections. The most common cause of late-onset sepsis was <I>Klebsiela p. </I>(31%) and followed by <I>Staph aureus </I>(18.1%). In this study, the researchers have observed that the old empiric therapy with cephalothine plus Amikacin for suspected late-onset sepsis seems ineffective. Now, however may be the best choice regimen is the combination vancomycin plus amikacin and the vancomycin plus imipenem for the severe ill patients.
ER  -