TY  - JOUR
T1  - Expression of IL-1α and PMN Leukocytes in Inflamed Pulp of Wistar Rat After Application
of Haruan Fish Extract (<i>Channa striata</i>)
AU - Jekti Nugroho, Juni AU - Sumidarti, Andi AU - Athriana Farma, Nenny AU - Natsir, Nurhayaty AU - Anastasia Rovani, Christine AU - Hikmah, Noor AU - Wisda Martianti, Andi AU - Harun Achmad, Muh. 
JO  - Journal of Dentistry Concerns
VL  - 1
IS  - 2
SP  - 20
EP  - 24
PY  - 2020
DA  - 2001/08/19
SN  - 2706-7467
DO  - jdc.2020.20.24
UR  - https://makhillpublications.co/view-article.php?doi=jdc.2020.20.24
KW  - Pulp capping
KW  -haruan fish extract
KW  -PMN leukocyte cells
KW  -IL-1&#945;
KW  -Wistar rat
AB  - Inflammation of permanent teeth that occurs in
reversible pulpitis, pulp capping therapy can be done to
keep the pulp healthy. Calcium hydroxide is the gold
standard material as a capping agent but it has
disadvantages due to its high pH. Haruan fish extract
(<i>Channa striata</i>) contains active compositions such as
albumin, unsaturated fatty acids and important minerals
that are needed in the inflammatory process, those can be
considered as an alternative medicine to subtitute calcium
hydroxide. To determine the effect of the application of
haruan fish extracts (<i>Channa striata</i>) on the number of
PMN leukocyte cells and the expression of IL-1 Alpha; in
the inflamed dental pulp of Wistar rat. Samples were 24
Wistar rats. Experimental animals were divided into 3
groups: negative control group, treatment group
(application of haruan fish extract), positive control group
(application of calcium hydroxide) to be decapitated in a
period of 12 and 72 h. Data were analyzed using the
Kruskall Wallis and Chi-square test. There was a
decreased in the number of PMN leukocyte cells and low
expression of IL-1 Alpha from strong staining to no
staining on histological examination and statistical
tests (p<0.05) according to observation time 12 and 72 h
in the treatment group. Haruan fish extract is effective in
decreasing PMN leukocyte infiltration and reducing IL-1&#945;
expression.
ER  -