TY - JOUR
T1 - Correlations of Glycosylated Hemoglobin with White Blood Cells and Platelets Counts in
Sudanese Non-Diabetics Population
AU - A. Ali, Ibrahim AU - H. Taha, Elmutaz
JO - Journal of Diabetes, Metabolism and Endocrinology
VL - 1
IS - 3
SP - 19
EP - 23
PY - 2020
DA - 2001/08/19
SN - 2708-2709
DO - jdme.2020.19.23
UR - https://makhillpublications.co/view-article.php?doi=jdme.2020.19.23
KW - Sudan
KW -platelets
KW -WBCs
KW -white blood cells
KW -HbA1c
KW -glycosylated hemoglobin
AB - Glycated Hemoglobin (HbA1c) is now used
largely for DM control. Previous studies showed different
relationship of HbA1c with White Blood Cells (WBCs)
and platelets counts. The aim of this study was to
investigate the correlation of glycated hemoglobin with
WBCs and platelets counts in non-diabetic Sudanese
population. A cross sectional study was conducted during
2016-2018 in Sudan covering Khartoum state, Northern
state, Gezira state, Red Sea state and North Darfur state
on adults of ages between 20-60 years and not known to
be diabetic or suffering from any chronic illness. The
1096 participants were assessed by a questionnaire and
physical examination. BMI and BP were calculated by
standard scales. A sample of 5 mL venous blood was
taken for FBG to exclude DM and measurement of HbA1c
using a modified ELISA reader known as Cobas Integra
800 (Roch) machine. A Sysmex KX-21 automated
hematology analyzer was used for measuring WBCs and
platelets counts. Correlations between the variables were
estimated and p<0.05 was considered statistically
significant. The mean age of the participants was found to
be 25.1±9.2 years with a range of 20-60 years. The
overall mean value of HbA1c was 4.6% ±0.9 with a
minimum value of 1.2% and maximums of 6.3. At 95%
confidence interval the lower bound Mean was 4.5% and
the upper bound mean was 4.7%. The reference range of
WBCs count in adult Sudanese was 2.9-9.6×103 μL–1
with a median of 5.0×103 μL–1. The reference range
of Platelets count in adult Sudanese was (124-465)×
103 μL–1 with a median of 280×103 μL–1. In overall
Sudan samples there was no correlation between WBCs
and HbA1c (r = -0.041; p = 0.200) but in the samples of
North Darfur and Northern states the WBCs count was
positively correlated with HbA1c with significant p value
(r = 0.185; p = 0.016) and (r = 0.241; p = 0.003),
respectively. In this study statistically significant
correlation was found between platelets count and HbA1c
level (r = 139; p = 0.000). The results suggest that WBCs
levels need to be taken into account when using HbA1c
levels to screen pre-diabetes or diabetes. Thus, measuring
Fasting Blood Glucose (FBG) or performing the Glucose
Tolerance Test (GTT) recommended to be considered
when diagnosing diabetes or pre-diabetes in patients in
the upper normal range of WBCs and close to the
diagnostic threshold of HbA1c level. Further, study
recommended to be done to investigate the level of WBCs
and HbA1c in Diabetic patients with measurement of
inflammatory marker to ensure whether the association
between WBCs level and HbA1c is mediated through
elevated glucose levels is caused by subclinical
inflammation. The Mean Platelets Volume MPV values
can be an effective marker for blood glucose. This exact
scientific phenomenon needs further analysis and
researches.
ER -