Min  Rahminiwati, La Ode  Sumarlin, Agik  Suprayogi, Aryani  Satyaningtijas, 
    <i>In vitro</i> Study of Namnam (<i>Cynometra cauliflora</i>) Leaf Extract on Glucose Uptake by Rat
Diaphragm,
    International Journal of Tropical Medicine,
    Volume 15,Issue 3,
    2020,
    Pages 60-65,
    ISSN 1816-3319,
    ijtmed.2020.60.65,
    (https://makhillpublications.co/view-article.php?doi=ijtmed.2020.60.65)
    Abstract: Diabetes Mellitus (DM) is a group of metabolic
disorder characterized by hyperglycemia due to damage
in insulin secretion, insulin action or both. One of the
diabetes mellitus group is diabetes mellitus type 2.
Diabetes accounts type 2 for most of the data of DM
patients which reached 90-95% of the total diabetics
population. One of the plants as a potential alternative
antidiabetic drugs is (<i>Cynometra cauliflora</i>) Namnam
plant. This research will test the ability of glucose
absorption by muscles of the isolated diaphragm of
Sprague Dawley rat by Namnam (<i>Cynometra cauliflora</i>)
leaf methanol extract at various concentrations. The result
shows that an increase in glucose uptake by diaphragm
when concentration of Namnam (<i>Cynometra cauliflora</i>)
leaf extract and the highest increases in the
concentration of 450 mg dL<sup>&#150;1</sup> with the uptake of
42.54&plusmn;3.23 mg dL<sup>&#150;1</sup>/30 min. Increased uptake of glucose
also occurs when insulin 0.25 IU mL<sup>&#150;1</sup> is combined
with methanol extract of namnam leaf (EMDN) at
concentration of 450 mg dL<sup>&#150;1</sup> of 92.19&plusmn;9.74 mg dL<sup>&#150;1</sup>/30
min. Therefore, the namnam leaf (<i>Cynometra cauliflora</i>)
plant has potential as antidiabetes type 2 drug
through mechanism of the increased glucose uptake into
cells.
    Keywords: Cynometra cauliflora;diabetes mellitus;glucose uptake;rat diaphragm;hyperglycemia