Fateme  Sefid, Nazgol  Emamian, Vahide  Saeidjavan, Sepide  Akhgari, Hamed  Karamizade, 
    In Silico Potential Vaccine Against Outer Membrane Protein 2 in
<I>Haemophilus parasuis</I>,
    Journal of Engineering and Applied Sciences,
    Volume 12,Issue 8,
    2017,
    Pages 1992-1998,
    ISSN 1816-949x,
    jeasci.2017.1992.1998,
    (https://makhillpublications.co/view-article.php?doi=jeasci.2017.1992.1998)
    Abstract: Haemophilus parasuis is a gram-negative bacterium belonging to the Pasteurellaceae family. This
organism is an important respiratory-tract pathogen in swine and the etiological agent of porcine polyserositis,
meningitis and arthritis syndrome known as Glasser&#146;s disease. Among the 15 known serovars, serotype 5
shows high virulence and is one of the most prevalent serotypes. Attempts to control the H. parasuis
infection are hindered by a lack of thorough knowledge of the virulence factors and protective antigens of the
bacterium, the existence of diverse genetic make-ups and the evolution of multidrug-resistant strains. Initial
studies about the immune response developed against H. parasuis have detected antibodies to Outer
Membrane Proteins (OMPs) but not against lipopolysaccharide or capsule, suggesting that the OMPs are more
immunogenic than other components of bacteria. In recent years, interest has shifted toward protein based
vaccines. It has been shown that recombinant vaccines based on OMPs provided partial protection against
challenge with H. parasuis.
    Keywords: Haemophilus parasuis;OMP;bioinformatic;immune response;partial protection