International Journal of Tropical Medicine
ISSN: Online 1818-779XISSN: Print 1816-3319
Abstract
Bacterial sepsis poses significant health risks to newborns, contributing substantially to both morbidity and mortality rates. The identification of probable sepsis involves clinical and laboratory findings indicative of bacterial infection in the absence of positive culture results. This study aims to investigate and ascertain the predictive utility of hematological parameters for early detection of neonatal sepsis within a tertiary care facility located in India. Conducted prospectively at a tertiary care teaching hospital in India, this research enrolled 145 neonates admitted to the neonatal intensive care unit. Neonates exhibiting clinical suspicion of sepsis or possessing predisposing perinatal factors were included. The study evaluated a hematological scoring system (HSS) alongside patients' clinical profiles and sepsis screening tests. Sensitivity, specificity, and positive predictive value (PPV) of each parameter were determined and analyzed. Among the 61 cases with culture‐confirmed sepsis, 53 infants (86.88%) displayed a score of $5, while 8 infants (13.11%) scored 3–4. the HSS demonstrated a sensitivity of 85.94% and specificity of 77.62%, with a PPV of 75.16%. Males exhibited a higher susceptibility to sepsis compared to females. Given the absence of any singularly superior hematological parameter in predicting neonatal sepsis, the combination of these parameters, along with C‐reactive protein, is advocated. The study concludes that HSS serves as a valuable tool in distinguishing infected neonates from non‐infected ones.
How to cite this article:
Kumar Shantnu, Pushpraj Singh Baghel, Prachi Kori and Shashank Tyagi. Early Diagnosis of Neonatal Septicemia Through Hematological Parameters at a Tertiary Care Center in India.
DOI: https://doi.org/10.36478/10.59218/makijtm.2024.1.84.87
URL: https://www.makhillpublications.co/view-article/1816-3319/10.59218/makijtm.2024.1.84.87