Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
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Endothelin in Bronchial Biopsy Specimens from Horses with Recurrent Airway Obstruction
Laus Fulvio, Paggi Emanuele, Mariotti Francesca, Cerquetella Matteo, Sgariglia Stefano and Tesei Beniamino
Page: 3647-3651 | Received 21 Sep 2022, Published online: 21 Sep 2022
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Abstract
Recurrent Airway Obstruction (RAO) is a chronic, worldwide recognized diseases of horses. Despite the well known clinical presentation and the ease of diagnosis, the exact etiology and pathogenesis are still unclear which makes it difficult prevention and treatment. Recurrent obstruction of airway is caused by mucus production, bronchospasm and bronchial edema and the most important clinical signs are chronic cough and expiratory effort. The ET-1 is the most potent vasoconstrictor molecule up to now identified, produced by several cells as endothelial cells, smooth muscle cells and epithelial cells of airways. The ET-1 is a potent proinflammatory, secretagogues and bronchoconstrictors mediator. ET-1 can cause bronchial contraction on bronchial rings of horses in vitro, especially in horse with respiratory disease.
How to cite this article:
Laus Fulvio, Paggi Emanuele, Mariotti Francesca, Cerquetella Matteo, Sgariglia Stefano and Tesei Beniamino. Endothelin in Bronchial Biopsy Specimens from Horses with Recurrent Airway Obstruction.
DOI: https://doi.org/10.36478/javaa.2012.3647.3651
URL: https://www.makhillpublications.co/view-article/1680-5593/javaa.2012.3647.3651