Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Osteoporosis treatment is rarely applied in clinics because osteoporosis is a silent disease, which is primarily diagnosed after patients have experienced the first fragility fracture. Even after such a fracture, under‐treatment is common, because only 10‐20 % of patients receive adequate treatment. Vitamin D affects the rate of bone turnover and the overall mineralization of the bone. Thus, vitamin D deficiency is associated with a higher bone turnover and incidence of fracture. It is likely that deficiencies in calcium and vitamin D negatively influence fracture healing. In osteoporotic vertebral compression fractures (OVCFs), supplementation using vitamin D preparations and maintenance of blood vitamin D level within the normal range are necessary for proper fracture union, enhancement of muscle strength and maintenance of body balance. There is still no consensus on what is the best supplementation strategy, in terms of dosage, frequency of treatment and duration and even in terms of fracture union rate, mineralization process, union time and complication rate in OVCF. Hence, we did a study is to confirm the effects of vitamin D supplementation after the onset of OVCF. It is a prospective study done in 30 patients with OVCF in Sree Mookambika Institute of Medical Sciences, Kulasekharam. We have included, Recent OVCF at $1 vertebra level on a simple radiograph, No other abnormal findings of the spine (e.g., infection, tumor), Low serum (OH) vitamin D level (< 30 ng/ml). Total 30 patients were divided into two groups, group‐1 includes 15 patients who received the 6 months course of Vitamin‐D supplement (Cholecarciferol) 60,000 IU/ week for first 8 weeks followed by 60,000IU twice a month for 4 months and group‐2 includes remaining 15 patients doesn’t receive Vitamin‐D supplement. Both groups were given same analgesics, braces along with supportive measures along with nutritional advice. Simple radiographs were taken to assess fracture union and the serum Vitamin‐D level was also monitored by during the follow up period. The severity of low back pain (LBP) was evaluated using a visual analog scale (VAS) with levels 0 to 10. To evaluate functional outcome, Oswestry Disability Index (ODI, version 2.0) and Roland Morris Disability Questionnaire (RMDQ) were used to follow up the patients during intial, 3 months and 6 months. The mean union time of group‐1 and group 2 is 12.06±1.06 weeks and 13.3±0.99 weeks respectively. The mean Serum 25(OH) Vitamin‐D levels of group 1 patients who received Vitamin‐D supplementation done during initial, after 3 months and 6 months follow up are 15.4± 3.61, 20.93±3.49 and 28.85±3.38 respectively and the mean Serum 25(OH) Vitamin‐D levels of group 2 patients done during initial, after 3 months and 6 months follow up are 15.67±2.98, 16.4±2.93 and 16.53±3.09 respectively. Our study had significance which gives marginal improvement in functional outcome of osteoporotic vertebral compression fractures by vitamin‐D supplementation and a significant improvement in the levels of serum (OH)‐D which is beneficial in vitamin‐D deficiency patients in maintaining the serum (OH)‐D levels and improving calcium bone homeostasis. Vitamin‐D supplementation is necessary that it can relatively reduce the risk of future osteoporotic fractures.
How to cite this article:
N. Kattu Bava, Zakir Hussain Mohammed, T.T. Annamalai, K.C. Mathew and Mohammed Sheriff. Is Vitamin‐D Supplementation Has Effect in the Functional Outcome of Osteoporotic Vertebral Fractures.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.261.266
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.261.266