Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Asthma, a chronic disease of the air passages which is characterized by airway inflammation and narrowing. The response to bronchodilators reflects the reversibility of airway airflow obstruction in asthmatic patients. Bronchodilator Reversibility varies with chronicity of asthma. 1 To assess FEV1 before and after nebulization with SABA‐salbutamol. 2 To assess chronicity in children using GINA checklist 3. To find out the association of reversibility with chronicity. Cross‐sectional study, 90 Children aged 5‐15 years old with diagnosis of asthma was recruited from Department of Paediatrics Chronicity was recorded using GINA checklist. FEV1 before and after 20 minutes of nebulisation with SABA noted. The reversibility of FEV1 after nebulization was categorised as <12% and >12%. Children with asthma, the chronicity is classified into <1 year, 1‐3 years, 3‐5 years, >5 years. The data was computed in Microsoft Excel 2023. Statistical analysis was done using SPSS version 20.0. Paired t test, Chi square test, Fischer’s exact test and Post hoc test are used for the analysis. Reversibility of > 12 % post nebulization (57 %), while the rest 43 % had reversibility of <12 %. Majority of the participants with reversibility >12 % had h/o asthma in < 1 year and The difference in the FEV1 reduced as the chronicity of asthma increased. The mean FEV1 before nebulisation and after nebulisation showed significant difference with p<0.00. In children with chronicity >5 years, 66.7% showed reversibility and <1 year, 44.4% showed reversibility. By Fischer’s exact test association between the reversibility of FEV1 in asthma and chronicity assessed were not statistically significant. As chronicity increases, airway reversibility also increases. Thus, Bronchodilator reversibility is a reliable marker of chronicity of asthma in children
How to cite this article:
Masaraddi Sanjay Krishna, M.S. Shiffana Rukkya and K.E. Elizabeth. FEV1 Reversibility after Nebulisation with Short Acting Beta Agonist in Relation to Chronicity of Asthma.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.308.310
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.308.310