Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Cataract surgery, a common procedure improving visual acuity, can be complicated by cystoid macular edema (CME). Glaucoma patients, often treated with prostaglandin analogues to lower intraocular pressure (IOP), may face an increased risk of CME due to the inflammatory nature of these medications. This study investigates the incidence and severity of CME in glaucoma patients using prostaglandin analogues post‐cataract surgery. To evaluate the incidence and severity of CME in glaucoma patients using prostaglandin analogues after uneventful cataract surgery. Compare CME incidence between prostaglandin analogue users and non‐users. Assess CME severity via optical coherence tomography (OCT). Determine CME development timeline post‐surgery. A randomized controlled trial was conducted with 100 glaucoma patients scheduled for cataract surgery, divided into two groups: Prostaglandin (n=50) and Control (n=50). The Prostaglandin Group continued their prostaglandin analogue therapy, while the Control Group did not. Primary outcome was CME incidence at 1, 4 and 12 weeks post‐surgery, assessed by OCT. Secondary outcomes included CME severity, visual acuity, anterior chamber inflammatory response and additional intervention needs. Baseline characteristics were similar between groups. CME incidence was higher in the Prostaglandin Group at all time points, reaching statistical significance at 12 weeks (20% vs. 8%, p=0.05). CME severity, indicated by central subfield thickness, was significantly greater at 12 weeks in the Prostaglandin Group (330 ± 35 μm vs. 310 ± 25 μm, p=0.04). Visual acuity was worse in the Prostaglandin Group at 12 weeks (0.2 ± 0.1 vs. 0.1 ± 0.1 logMAR, p=0.03). Anterior chamber inflammatory response was higher in the Prostaglandin Group but not significantly so. Additional interventions were more frequent in the Prostaglandin Group (32% vs. 16%, p=0.04). Glaucoma patients using prostaglandin analogues post‐cataract surgery exhibited higher incidence and severity of CME, poorer visual outcomes and increased need for interventions. These findings suggest the need for careful consideration of prostaglandin analogue use in perioperative care for cataract surgery in glaucoma patients.
How to cite this article:
B. Vaduva Krishnan, R. Aalathi, Biju Gopal, R. Hannah Shiny and R. Jeyanthi. Cystoid Macular Edema with Prostaglandin Analogue use after Uneventful Cataract Surgery in Glaucoma Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.375.380
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.375.380