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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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Elevated Serum Transaminases: Aspartate Aminotransferase and Alanine Aminotransferase Among Leptospirosis Patients Admitted in a Tertiary Level Teaching Hospital

Hanumanthakari Prudhvirajrana, K. Preetham, Devadas Rai, Koot Snehal Rajkumar, Mohammed Bilal Hussain, K.A. Ateeb Ahmed and Y. Praneeth Charan Reddy
Page: 42-45 | Received 28 Apr 2024, Published online: 04 Jun 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.7.42.45

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Abstract

The aim of the present study was to estimate the proportion of elevated serum transaminases and to study the clinical profile of Leptospirosis patients with transaminitis and disproportionate rise in AST admitted in tertiary level teaching hospital. This cross‐sectional study was conducted in the Department of General Medicine KIMS Mangalore in the year of 2023 in monsoon season with 105 patients. All patients diagnosed as Leptospirosis by Modified Faines criteria. Exclusion criteria‐patients having previously diagnosed chronic liver disease, serologically diagnosed Dengue fever, Hepatitis A, Alcoholic liver disease. The mean age was found to be 37.9±12.1 years. 81% were males and 19% were females. 45.7% of study population was manual labourers. In this study fever myalgia observed in all patients, Jaundice seen in 32.4%, Headache was present in 67.6%, Conjuctival suffusion in 28.6%, Hemoptysis in 6.7% of patients, Tachycardia, Hypotension, Reduced urine output in 32.4%, 26.7% and 15.2%. 94 patients have elevated AST which comprised of 89.5% of study population. 94 patients have elevated AST which comprised of 89.5% of study population. 86 patients have elevated ALT which comprised 81.9% Population. 24 patients (23%) have disproportionte rise in AST with values more than 3 times compared to ALT. Renal failure was the most common complication seen in this study, seen in 45 patients which constitutes 42.9%. Non‐oliguric AKI is observed in most patients. Respiratory failure was seen in 16 patients which constitutes 15.2%. Shock is seen in 28 patients which constitutes 26.7%. MODS is seen in 8 patients which constitutes 7.6%. A Disproportionate rise in AST when compared to ALT with AAR i.e., AST/ALT $3 is associated with higher mortality rate. Respiratory failure, coagulopathy and MODS are common if AAR $3.

How to cite this article:

Hanumanthakari Prudhvirajrana, K. Preetham, Devadas Rai, Koot Snehal Rajkumar, Mohammed Bilal Hussain, K.A. Ateeb Ahmed and Y. Praneeth Charan Reddy. Elevated Serum Transaminases: Aspartate Aminotransferase and Alanine Aminotransferase Among Leptospirosis Patients Admitted in a Tertiary Level Teaching Hospital.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.42.45
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.42.45