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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Study on Histopathological Evaluation of Tumor Infiltrating Lymphocytes (TIL’s) in Correlation With Molecular Subtypes, Tumor Grade and Stage of Breast Cancer

Y. Aishwarya, B.M. Vara Prasad and Atira Mirza
Page: 469-473 | Received 27 Apr 2024, Published online: 25 Jun 2024

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https://doi.org/10.36478/10.36478/makrjms.2024.7.469.473

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Abstract

Tumour‐infiltrating lymphocytes (TILs) exhibit anti‐tumoral immunity and have the potential as a prognostic marker, especially in triple‐negative and human epidermal growth factor receptor 2‐over expressing breast cancer. The study aims to evaluate the correlation between TILs and molecular subtypes, tumour grading and stage of breast cancer. Materials and The study was a cross‐sectional study carried out at Ramaiah Medical College over three months from May to July 2023, comprising 40 cases of breast carcinoma. Breast cancer tissue was examined using Haematoxylon and Eosin (H and E) and Immunohistochemistry (IHC) staining, in addition to the assessment of lymph node involvement, tumour grading and staging. In the study of 40 cases, the most common histological type was invasive ductal carcinoma (95%). The Luminal A subtype was the most common variant observed. It was associated with low levels of Stromal tumour infiltrating Lymphocytes (sTIL) and Intratumoral infiltrating lymphocytes (iTIL) scores in comparison with triple‐negative and Her‐2 positive tumours, which had higher levels of sTILs and iTILs. In the present study sTIL and iTIL scores increased with tumour grade, size, mitosis and staging. The study concludes that tumor infiltrating lymphocytes are an easily accessible, affordable marker for estimating the tumor grade and stage of breast cancer and must be incorporated in every screening test panel for breast cancer.

How to cite this article:

Y. Aishwarya, B.M. Vara Prasad and Atira Mirza. A Study on Histopathological Evaluation of Tumor Infiltrating Lymphocytes (TIL’s) in Correlation With Molecular Subtypes, Tumor Grade and Stage of Breast Cancer.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.469.473
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.469.473