Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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To Study and Compare the Antimicrobial Susceptibility Pattern of Methicillin Resistant Staphylococcus Aureus (MRSA) and Methicillin Resistant Coagulase Negative Staphylococci (MRCONS)
Rakhi Dixit, Jagadevi and Pooja Mansabdar
Page: 582-587 | Received 30 Apr 2024, Published online: 09 Jul 2024
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Abstract
Antimicrobial resistance (AMR) is a leading cause of death around the world, with the highest burden in low‐resource settings. It is important to expand microbiology laboratory and pharmacy capacity for surveillance. Empirical antibacterial therapy should be based on several considerations, including patient risk factors, expected pathogens and local / regional susceptibility profiles, among others. Hence, Antimicrobial Susceptibility Testing (AST) is the most important investigation carried out by a clinical microbiology laboratory and it plays a vital role to guide the clinician in tailoring the empirical antimicrobial therapy to pathogen‐directed targeted therapy. It is also important to monitor antimicrobial susceptibility pattern of common hospital pathogens. The guidelines on AST are regularly revised and need to be consulted regularly. Most of the studies done previously have concentrated on studying the antimicrobial susceptibility pattern of clinical isolates from patients. In contrast, in our study, we evaluated the antimicrobial susceptibility patterns of the staphylococcal isolates obtained from the healthcare workers (HCWs) during their screening for MRSA carriage. As the pathogenic role of coagulase negative staphylococci is increasingly being reported, a detailed AST for MRCONS was also done and compared with the patterns in MRSA isolates. All the staphylococcal isolates were sensitive to vancomycin, teicoplanin and linezolid whereas no isolate was sensitive to penicillin G. MRCONS isolates were found to be more sensitive to many common antibiotics like co‐trimoxazole, ciprofloxacin, erythromycin, gentamicin, amikacin and rifampicin as compared to MRSA isolates but the differences were not statistically significant (p‐value > 0.05). The high antibiotic resistance of MRSA is very concerning because it can lead to treatment failure in clinical practice. A robust antimicrobial stewardship and strengthened infection control measures are required to prevent spread and reduce emergence of resistance. Continuous surveillance of multidrug resistant organisms (MDROs) in a healthcare setting is a necessity to have optimum treatment outcome and less of treatment failures.
How to cite this article:
Rakhi Dixit, Jagadevi and Pooja Mansabdar. To Study and Compare the Antimicrobial Susceptibility Pattern of Methicillin Resistant Staphylococcus Aureus (MRSA) and Methicillin Resistant Coagulase Negative Staphylococci (MRCONS).
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.582.587
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.582.587