Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Chronic Urticaria (CU) is a persistent, distressing skin condition characterized by the daily or almost daily occurrence of itchy, spontaneous wheals for more than six weeks. Traditional treatments often involve nonsedative antihistamines and immunomodulators, which may not provide long‐term relief. Histaglobulin, combining histamine dihydrochloride and human immunoglobulin, has been evaluated for its potential to improve treatment outcomes in CU. Aim of the study was to assess the efficacy of histaglobulin in reducing the severity of symptoms in patients with chronic spontaneous urticaria and its ability to decrease the dependency on antihistamines. A single‐centre, open‐label, prospective clinical study was conducted at Mamata General Hospital's Dermatology Venereology and Leprosy Outpatient Department from October 2023 to May 2024. Thirty patients aged 18‐60 with chronic spontaneous urticaria were enrolled after obtaining informed consent. Patients were administered a subcutaneous injection of histaglobulin weekly for eight weeks and followed up until the 24th week. The primary outcome measure was the change in the Urticaria Activity Score over 7 days (UAS 7) from baseline to week 8. Out of 30 patients, 28 completed the study. The initial mean UAS 7 score was 28, which reduced to 10 by week 8, indicating a 64% reduction. Eight patients (35%) achieved complete response (UAS 7 = 0). All participants who completed the study reduced or stopped their antihistamine usage. The improvement was statistically significant (p<0.0001). Histaglobulin significantly reduced the severity of urticaria symptoms and the use of rescue medication in patients with chronic spontaneous urticaria. It was well‐tolerated with no adverse effects reported, suggesting its utility as an effective alternative to traditional therapies, potentially offering long‐term remission.
How to cite this article:
B.U.P. Lakshmi, Kotha Alekhya, Sangem Sagarika and Sadula Apoorva. Histaglobulin: An Elixir for Treatment of Chronic Urticaria.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.7.6.9
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.7.6.9