Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Spectrum of Microbial Infections and its Antimicrobial Susceptibility Pattern in Cancer Patients at a Tertiary Cancer Centre Mahavir Cancer Sansthan Phulwari Sharif Patna
Neelima Singh, Pallavi Priya and Shivani Mishra
Page: 1-4 | Received 28 May 2024, Published online: 05 Jul 2024
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Abstract
Patients with malignancy undergoing therapy are at increased risk of nosocomial infections due to prolonged hospital stays, immunocompromised states interventional treatment modalities. Infections remain a significant cause of morbidity and mortality among cancer patients, exacerbated by antimicrobial resistance, which is a growing concern. This study aims to evaluate the prevalence of infections caused by various microbes and their antimicrobial susceptibility patterns in cancer patients at a tertiary care center, Mahavir Cancer Sansthan, Phulwari Sharif, Patna. A retrospective analysis was conducted on patients admitted for cancer treatment and diagnosed with infections from January 9, 2023‐December 8, 2023, at Mahavir Cancer Sansthan, Patna. Various clinical specimens were collected and processed using standard microbiological techniques, including staining, culture antimicrobial susceptibility testing. Data on demographic and clinical characteristics were collected from patient case files and analyzed to determine infection prevalence and antimicrobial susceptibility patterns. A total of 980 patients were included, with 490 having documented infections. The mean age of infected patients was 55.3±10.4 years, with a gender distribution of 280 males and 210 females. The most common infections were urinary tract infections (UTIs) (30.6%), followed by body fluid infections (22.4%), pus/infected wounds (18.4%), bloodstream infections (BSIs) (16.3%), respiratory tract infections (8.2%)sterile body fluid infections (4.1%). Klebsiella spp. was the most frequently isolated pathogen. Antimicrobial susceptibility testing revealed varying resistance patterns, with Klebsiella spp. showing 40% resistance to amoxicillin‐clavulanate and 80% susceptibility to imipenem. Patients with longer hospital stays had higher infection rates, with 20% of those staying more than 21 days being infected. The study highlights a significant burden of nosocomial infections among cancer patients, with a high prevalence of UTIs, BSIs, respiratory tract infections. The findings underscore the critical need for effective infection control measures and antimicrobial stewardship programs to manage infections and reduce antimicrobial resistance, ultimately improving patient outcomes.
How to cite this article:
Neelima Singh, Pallavi Priya and Shivani Mishra. Spectrum of Microbial Infections and its Antimicrobial Susceptibility Pattern in Cancer Patients at a Tertiary Cancer Centre Mahavir Cancer Sansthan Phulwari Sharif Patna.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.1.4
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.1.4