Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Human Papillomavirus (HPV) is a significant causative agent of cervical cancer, the fourth most common cancer among women worldwide. Understanding the prevalence and genetic diversity of HPV in cervical cancer patients is crucial for developing targeted interventions and vaccines. This study employed a cross‐sectional design with a sample size of 240 cervical cancer patients from a tertiary care hospital. HPV DNA was extracted from cervical samples and genotyped using polymerase chain reaction (PCR) followed by sequencing to identify prevalent HPV types. The study identified high‐risk HPV types in 85% of the samples, with HPV 16 and 18 being the most prevalent. Additionally, the genetic analysis revealed multiple HPV infections in 20% of the samples, indicating significant genetic diversity. The high prevalence of HPV, particularly high‐risk types, underscores the need for enhanced screening and vaccination programs. The genetic diversity of HPV suggests the potential for region‐specific vaccine development to improve efficacy.
How to cite this article:
Nisha Singh, Sanjay Kumar and Alpana Singh. Prevalence and Genetic Diversity of Human Papillomavirus (HPV) in Cervical Cancer Patient.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.170.174
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.170.174