Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Osteoarticular tuberculosis (OATB) poses significant diagnostic and therapeutic challenges due to its insidious onset and potential for drug resistance. Rapid and accurate detection of drug resistance is crucial for effective management. This study compares the diagnostic efficacy of Cartridge‐Based Nucleic Acid Amplification Test (CBNAAT) and TrueNAT in detecting drug resistance patterns in OATB patients at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna.A total of 100 patients diagnosed with OATB were enrolled in this comparative study conducted from March 2022 to February 2024 at the Department of Microbiology, IGIMS, Patna. Samples collected from osteoarticular sites were subjected to both CBNAAT and TrueNAT tests to detect Mycobacterium tuberculosis and determine drug resistance. Sensitivity, specificity, turnaround time, and drug resistance patterns were evaluated for both diagnostic methods. Among the 100 samples tested, Cbnaat detected mycobacterium bacilli in 88% of the cases, while True Nat detected the bacilli in 87.5 % of the cases. drug resistance pattern was identified in 32 % of the CBNAAT positive cases and 30 % of the TrueNAT positive cases. The sensitivity and specificity of cbnaat are found to be 97 % and 95 % respectively Whereas True Nat demonstrated a sensitivity 96 % and specificity of 94 % the average time for CBNAAT was 2 hours, compared to 1.5 hours for True Nat. Both Cbnaat and True Nat are effective diagnostic tools for detecting mycobacterium tuberculosis and drugs resistance patterns in ostoarticular tuberculosis. Cbnaat shows a slightly higher sensitivity and specificity, with a slower turnaround time compared to True Nat. Thease finding supports the use of True Nat as a reliable alternative for the rapid diagnosis and management of drugs resistance OSTB.
How to cite this article:
Bajrangi Ram, Sejal Raj, Rakesh Kumar, Sweta Muni, Shailesh Kumar and Namrata Kumari. A Comparative Study Between CBNAAT and Truenat on Pattern Of Drug Resistance in Osteoarticular Tuberculosis.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.296.299
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.296.299