Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Effect of Single Dose of Dexamethasone on Peri Operative Blood Glucose Levels in Non‐Diabetic Patients Undergoing Laparoscopic Cholecystectomy
Komal R. Deshpande, D. Abhishek, M.G. Harshitha, K.C. Anamika Prem, M.S. Nataraj and N. Javagal Amith Thejas
Page: 360-365 | Received 10 Jun 2024, Published online: 25 Jul 2024
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Abstract
Laparoscopic cholecystectomy is associated with an increased risk of postoperative nausea and vomiting. Dexamethasone, a potent corticosteroid has antiemetic, analgesic action. A single dose increases blood glucose levels even in non‐diabetics. We estimated perioperative blood glucose levels after the administration of 8 mg intravenous dexamethasone in non‐diabetic patients undergoing laparoscopic cholecystectomy. Ethical committee approval and informed written consent were obtained from all 70 patients in this prospective randomized study. Two groups of 35 patients each received 8 mg intravenous dexamethasone or saline at induction and underwent laparoscopic cholecystectomy. Capillary blood glucose was measured at baseline and 1, 2, 4 and 6 hours. Diabetic patients were excluded. Statistical analysis was done using measures dispersion, Mann Whitney U test and Friedman’s test. Demographic data, ASA status, type of surgery and duration of anaesthesia were comparable between both groups. In our study, after administration of 8 mg I.V. dexamethasone at induction, blood glucose levels increased from baseline (mean=87.5±7.8), peaked at 2 hours (mean=134.7±19.9), up to 6 hours (mean=127.6±13.8) in Group D while in Group S the mean glucose levels gradually increased from T0 (mean=84.9±8.9) to T6 (mean=110.9±16). When non‐diabetic patients undergoing laparoscopic cholecystectomy are administered a single dose of 8 mg intravenous dexamethasone at induction of general anaesthesia, the blood glucose levels rise at various points throughout the perioperative period. This rise was within a range that was clinically acceptable and was not substantial enough to have an adverse effect that was clinically evident.
How to cite this article:
Komal R. Deshpande, D. Abhishek, M.G. Harshitha, K.C. Anamika Prem, M.S. Nataraj and N. Javagal Amith Thejas. Effect of Single Dose of Dexamethasone on Peri Operative Blood Glucose Levels in Non‐Diabetic Patients Undergoing Laparoscopic Cholecystectomy.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.360.365
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.360.365