Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Membranous Nephropathy (MN) is a prevalent cause of nephrotic syndrome and proteinuria worldwide. It is characterized by diffuse thickening of the glomerular capillary wall due to immune complex deposition. The aim of this study is to elucidate the clinical and pathological features of MN and evaluate the response to treatment in a tertiary center located in Anathapur District. This study involved a prospective analysis of 46 patients diagnosed with MN at a tertiary care hospital. Data were collected regarding patient demographics, clinical presentation, pathological findings and response to various treatment modalities. The cohort comprised 20 female and 26 male patients, with a mean age of 40.65 years. Clinical parameters such as presence of nephrotic syndrome, hypertension, and microscopic hematuria were recorded. Pathological findings were correlated with serum creatinine levels and degree of proteinuria. Treatment responses were assessed based on clinical remission status. Among the 46 patients, 32 presented with nephrotic syndrome, 19% had concurrent hypertension, and 23.9% exhibited microscopic hematuria. The pathological stage of MN showed a significant correlation with serum creatinine levels, suggesting an association with renal function impairment. However, there was no significant correlation between pathological stage and the degree of proteinuria. Treatment led to complete remission in 48% of the patients. This study provides valuable insights into the clinical and pathological characteristics of MN in Anathapur District. It highlights the prevalence of nephrotic syndrome and the variability in clinical presentation. The correlation between pathological stage and serum creatinine underscores the importance of assessing renal function in MN patients. The finding that nearly half of the patients achieved complete remission underscores the effectiveness of current treatment modalities. These results are crucial for optimizing management strategies and improving patient outcomes based on individual clinical profiles.
How to cite this article:
Mitta Venkata Krishna Hareesh. Clinicopathological Features of Membranous Nephropathy in a Tertiary Center in Anathapur District.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.486.490
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.486.490