Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Septicemia is, when a micro‐organism enters the bloodstream from elsewhere in the body, such as the: skin, lungs, kidneys, bladder. It is a life‐threatening condition which must be treated otherwise it will lead to sepsis and other complications. It is difficult to differentiate sepsis from other non‐infectious conditions in critically ill patients admitted with systemic inflammatory response syndrome. The prevalence of causative organism causing sepsis differs from region to region depending on the systemic involvement. The treatment of sepsis is very challenging due to emerging multidrug resistant (MDR) microorganisms. With the rising problem of drug resistance, the present study was undertaken to evaluate the clinical profile and the bacteriological profile causing bloodstream infections in adult patients with their antimicrobial sensitivity pattern. This study was aimed at isolating and identifying bacterial agents from blood culture and antimicrobial sensitivity as well as the clinical profile of the patients diagnosed clinically as having sepsis. A Cross‐Sectional observational study was conducted on 60 patients, who showed signs and symptoms of septicemia. All adult patients above 18 years, admitted to ICU with features of severe sepsis and septic shock as per SCCM/ACCP guidelines were included. Under aseptic conditions blood was drawn for culture and antibiotic susceptibility testing was performed for bacterial isolates on Muller‐Hinton agar. The antibiotic susceptibility testing of the isolates was done using Kirby‐Bauer disc diffusion method. Out of 60 patients, 32 were males and 28 were females, with mean age was 54.06 years with slight male preponderance. The most commonaffectedage group was above60 years. Most common source of infection was from the respiratory tract (40%) followed by intra‐abdominal (30%) infections and urinary tract infections. Out of 60 samples 58 (96.66%) samples showed bacterial growth. Out of the 60 isolates, 67.24% (39/58) were Gram negative bacilli, 32.75% (19/58) were Gram positive bacteria and 3.33% (2/60) were shown no growth. Among those Klebsiella spp.‐25.86% (15/58) was the most frequent isolate from blood culture followed by CoNS‐ 18.96% (11/58), Pseudomonas spp. 17.24% (10/58), E. coli 15.51% (9/58). In our study, Klebsiella showed sensitivity to Amikacin (60%) and Meropenem (53.33%), but resistance to Ceftriaxone (60%) and Ciprofloxacin (53.33%), whereas CoNS was highly sensitive to Pipericillin+Tazobactum (81.8%), but resistant to Azithromycin (72.72%), Ciprofloxacin (63.63%) and Clindamycin (63.63%).Pseudomonas and rest other microbes shown variable multidrug resistant. As treatment of sepsis is challenging because of raising multidrug resistance among both Gram‐positive and ‐negative organisms, the knowledge of their resistance patterns is critical in a local geographic area for adequate management of sepsis.
How to cite this article:
CHANDRAKALA , J. Abhinand, Sagar Bagodi and Syed Mohammed Hussaini. Study of Clinical and Bacteriological Profile of Adult Septicemia in Tertiary Care Hospital.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.8.62.67
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.8.62.67