Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Neurodegenerative disorders are marked by the gradual deterioration of nerve cells, with oxidative stress being a key contributing factor. This study aims to evaluate the levels of oxidative stress biomarkers Malondialdehyde (MDA) Glutathione (GSH) and Superoxide Dismutase (SOD) in individuals with neurodegenerative diseases compared to a healthy control group. A total of 100 participants were enrolled, including patients diagnosed with Alzheimer’s, Parkinson’s and Multiple Sclerosis, alongside age‐matched controls. Biomarker levels were measured using blood samples. Correlations between biomarker levels and disease severity, cognitive decline, and motor function were analyzed. The study found significantly higher levels of MDA and lower levels of GSH and SOD in the neurodegenerative disease group compared to controls. MDA showed a positive correlation with disease severity (r = 0.65) while GSH and SOD levels negatively correlated with cognitive decline (r = ‐0.60) and motor function (r = ‐0.55) respectively. Age was a significant factor, with older participants showing higher biomarker levels but no genderbased differences were observed. Specific findings for Alzheimer’s and Parkinson’s diseases included remarkably high MDA and low GSH levels, respectively. Statistical analyses confirmed the significance of these differences (p<0.01 for MDA and GSH). The study underscores the importance of oxidative stress biomarkers in understanding neurodegenerative diseases. Elevated MDA and reduced GSH and SOD levels could serve as potential indicators for disease progression and severity. Neurodegenerative diseases, oxidative stress, biomarkers, malondialdehyde, glutathione.
How to cite this article:
Maraju Sireesha and Jonnadula Mohana Lakshmi. The Role of Oxidative Stress Biomarkers in Neurodegenerative Diseases: Population Based Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.7.1120.1124
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.7.1120.1124