Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often leading to reproductive and metabolic complications. Metformin an insulin‐sensitizing agent, has been proposed as a treatment to improve reproductive outcomes in PCOS patients. This study aims to assess the impact of Metformin therapy on reproductive outcomes in women with PCOS. In this observational study, 100 women diagnosed with PCOS were included. Key parameters such as age, BMI, duration of PCOS and Metformin dosage (500‐1000 mg and 1500 mg) were recorded. The study also measured fasting insulin and glucose levels, and hormonal profiles (LH, FSH, LH/FSH ratio). The primary outcomes were ovulation, conception and live birth rates. Descriptive and inferential statistical analyses were employed to interpret the data. The mean age of participants was 31.54 years, with a mean BMI of 26.57. The average duration of PCOS was 4.97 years. The study observed an ovulation rate of 57% a conception rate of 45% and a live birth rate of 25%. The mean fasting insulin level was 12.83 μIU mLG1 and the mean fasting glucose level was 90.30 mg dLG1. Hormonal profile analysis showed an average LH/FSH ratio of 2.01. Metformin therapy demonstrated a positive impact on reproductive outcomes in women with PCOS, with significant rates of ovulation and conception and a notable live birth rate. This study suggests the potential of Metformin as a beneficial treatment option in managing reproductive aspects of PCOS. Further research is warranted to explore the long‐term effects and optimal dosing strategies of Metformin in different PCOS phenotypes. PCOS, metformin, reproductive outcomes, ovulation, conception, live birth, insulin resistance.
How to cite this article:
D. Kiran, Chandana Loke and Sudheer Kumar Kotagiri. The Impact of Metformin Therapy on Reproductive Outcomes in Women with PCOS: An Observational Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2023.7.1136.1139
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2023.7.1136.1139