Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Postoperative nausea and vomiting (PONV) remain a significant concern following surgical procedures, particularly in gynecological interventions such as hysterectomy. This study aims to compare the efficacy oftwo 5‐HT3 receptor antagonists, Ramosetron and Ondansetron, in preventing PONV in women undergoing hysterectomy. Both drugs have distinct pharmacokinetic profiles and this investigation seeks to evaluate their comparative effectiveness in reducing the incidence of nausea and vomiting during the postoperative period. A prospective single‐blinded randomized study was conducted on 60 healthy women aged 18‐65, undergoing abdominal hysterectomy under spinal anesthesia. Patients were randomly assigned to receive either Ramosetron (0.3 mg) or Ondansetron (4 mg). The evaluation of nausea and vomiting was performed using the PONV SCORE system at different time intervals (0‐6 hrs, 6‐12 hrs and 12‐24 hrs). The scoring system included categories for Complete Response, Nausea, Vomiting and the need for Rescue antiemetic. Statistical analyses were employed to compare the outcomes between the two groups. In the 0‐6 hrs. time interval, Ramosetron exhibited comparable efficacy to Ondansetron in reducing the PONV score, with statistically nonsignificant differences. However, during the 6‐12 hrs and 12‐24 hrs. intervals, Ramosetron demonstrated superior efficacy, significantly lowering the PONV score compared to Ondansetron. The incidence of nausea and vomiting was consistently lower with Ramosetron, especially during the later postoperative intervals. While both Ramosetron and Ondansetron were effective in preventing postoperative emesis, Ramosetron emerged as a more potent antiemetic, particularly in the 6‐12 hrs. and 12‐24 hrs. postoperative periods. The extended half‐life and higher receptor affinity of Ramosetron may contribute to its prolonged duration of action. These findings suggest that Ramosetron could be considered a favorable choice over Ondansetron for preventing PONV in women undergoing hysterectomy. The study contributes valuable insights into optimizing postoperative care strategies in gynecological surgeries.
How to cite this article:
Bhavesh B. Zinzala, Hardul V. Modi, Dhara Joshi and Jagdishbhai G. Mer. Comparison of Ramosetron with Ondansetron for Prevention of Nausea and Vomiting in Women
Undergoing Hysterectomy.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.2.148.154
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.2.148.154