Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Comparison of Two Different Doses of Buprenorphine as an Adjuvant to Ropivacaine in Ultrasonography (USG) Guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries
Dnyaneshwari Munde, Pradnya Shripad Joshi and Anuradha Jogdand
Page: 152-157 | Received 20 Nov 2023, Published online: 06 Jan 2024
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Abstract
Buprenorphine an opioid with mixed agonist antagonist property has been shown to provide longer duration of analgesia among all the opioids when used as an adjuvant for peripheral nerve block. The exact dose of the drug to be used is not studied much with head to head comparison of different doses. We compared two different doses of Buprenorphine 3 μg kg-1 Vs 4μg kg-1 as an adjuvant to Ropivacaine in ultrasonography (USG) guided supraclavicular block. The primary outcome of the study was to compare characteristics of sensory, motor blockade and duration of analgesia in both the groups. This prospective randomized double blind controlled trial was conducted in 60 patients of both sexes between age group of 18‐70 yrs, with ASA class 1, 2, 3, undergoing surgery under supraclavicular block. Group 1 received 0.5% ropivacaine 20ml + Buprenorphine (3mcg kgG1) Group 2 received 0.5% ropivacaine 20ml+ Buprenorphine (4mcg kg-1). We observed time of onset of sensory block, motor block, their duration and duration of analgesia. All statistical analysis was done using SPSS 21 for Windows (Statistical Package for Social Science). If p<0.05, it was considered as significant and p>0.05 as non‐significant. The mean dose of drug used in Group 1 was 176.8±23.4μg and in Group 2 was 240.5±41.5μg. The mean time of onset of sensory block was faster in Group 2 (4.08±1.29 min) than Group 1 (4.92±1.82 min), (p‐value = 0.067).The mean duration of sensory block was more in Group 2 (514.8±136.4 min) than Group 1 (457.8±135.65 min) (p‐value = 0.1450) The mean onset of motor block was earlier in Group 2 (15.24±1.81 mins) than Group 1 (15.64±1.78 mins) (p‐value = 0.4342). The mean duration of motor block was more in Group 2 (445±143 min) than in Group 1 (376±121min).The mean duration of analgesia was longer in Group 2 (954.40±88.60 mins) than Group 1 (834.92±65.31 mins), P value 0.0001 which shows statistically highly significant difference. Buprenorphine when used as an adjuvant with 20 ml ropivacaine in USG guided supraclavicular block, in the dose of 3μg kg-1 and 4μg kg-1 has comparable sensory and motor block characteristics, without any side effects although 4μg kg-1 provides longer duration of analgesia and reduced requirements of postoperative rescue analgesics, hence it may be preferred over 3μg kg-1 dose.
How to cite this article:
Dnyaneshwari Munde, Pradnya Shripad Joshi and Anuradha Jogdand. Comparison of Two Different Doses of Buprenorphine as an Adjuvant to Ropivacaine in Ultrasonography (USG) Guided Supraclavicular Brachial Plexus Block for Upper Limb Surgeries.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.152.157
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.152.157