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Research Journal of Medical Sciences

ISSN: Online 1993-6095
ISSN: Print 1815-9346
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A Prospective Comparative Study on Intravenous Labetalol and Oral Nifedipine for Control of Blood Pressure in Severe Pre‐Eclampsia

Sahu Devojit, Ramotra Rohini, Yogesh B. Malage, Kumar Manoj, D.P. Nandi and Haritha Nair
Page: 317-321 | Received 11 Jan 2024, Published online: 28 Feb 2024

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https://doi.org/10.36478/10.59218/makrjms.2024.4.317.321

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Abstract

Severe preeclampsia is the second common cause for maternal morbidity and mortality and also leads to fetal complications. Although hypertensive disorders in pregnancy cannot be prevented, early diagnosis and treatment (secondary prevention) helps in favourable maternal and foetal outcome. The most commonly recommended hypertensive drugs used in the management of preeclampsia include hydralazine ( i.v), labetalol (oral and i.v) and nifedipine (oral).The study was carried out on 60 pregnant women attending the antenatal OPD and emergency room at Moran Medical Centre, Dibrugarh, Assam. Patients were further divided into 2 groups (Group A‐ Labetalol injection was given 20 mg and Group B‐ nifedipine 10mg was given orally at 20 mins interval) The target blood pressure was 150/90 mm Hg and at this point study regimen was stopped. After the successful control of BP further antihypertensive was given orally as chosen by provider. The time interval and dosage of the drugs required to achieve the target BP was noted.  Mean SBP was 180.7±14.99 mm Hg in group A and 182.0±15.53 mm of Hg in group B (p = 0.7401). Mean DBP was 119.1±8.46 mm of Hg in group A and 117.7±8.89 mm of Hg in group B (p = 0.5407). Most of the patients were controlled by two doses of each drug, 56.67% in the labetalol group and 60% in the Nifedipine. Labetalol had less maternal side effects when compared to nifedipine. Labetalol seems to be safer, with quick control of blood pressure with fewer side effects.

How to cite this article:

Sahu Devojit, Ramotra Rohini, Yogesh B. Malage, Kumar Manoj, D.P. Nandi and Haritha Nair. A Prospective Comparative Study on Intravenous Labetalol and Oral Nifedipine for Control of Blood Pressure in Severe Pre‐Eclampsia.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.317.321
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.317.321