Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Bacterial conjunctivitis is a common ocular condition requiring effective antimicrobial treatment to prevent complications and transmission. This study aimed to compare the efficacy of various antibiotics in treating bacterial conjunctivitis, considering resolution rates, antibiotic resistance patterns, adverse effects and recurrence rates. A prospective, randomized, comparative study was conducted on 200 patients diagnosed with bacterial conjunctivitis at the Department of Ophthalmology, Kamineni Institute of Medical Sciences, Narketpally. Patients were randomly assigned to receive either ciprofloxacin 0.3% eye drops or moxifloxacin 0.5% eye drops, administered four times daily for 7 days. The primary outcome measures included the resolution of symptoms and bacterial eradication, while secondary outcomes focused on adverse effects, antibiotic resistance and recurrence within three months post‐treatment. Moxifloxacin demonstrated a slightly higher resolution rate (92% vs. 85% for ciprofloxacin) and a shorter mean time to symptom resolution. Antibiotic resistance was more pronounced for ciprofloxacin, especially against Staphylococcus aureus and Moraxella lacunata. Adverse effects were minimal across both treatment groups, affecting only 10% of patients, primarily as mild allergic reactions and local irritation. The recurrence rate of bacterial conjunctivitis within three months post‐treatment was 7.5%, with no significant difference between the treatment groups. Moxifloxacin showed a marginally higher efficacy in treating bacterial conjunctivitis compared to ciprofloxacin, with a quicker resolution of symptoms and lower antibiotic resistance rates. Despite the similar safety profiles and recurrence rates, antibiotic selection should be guided by local resistance patterns and individual patient factors to optimize treatment outcomes. The findings underscore the importance of antibiotic stewardship in managing bacterial conjunctivitis effectively.
How to cite this article:
Kompalli Rohit Kumar, P. Sudhirbabu, Mamathashetty and K. Tejaswi. Comparative Efficacy of Antibiotics in the Treatment of Bacterial Conjunctivitis An Institutional Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.332.337
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.332.337