Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
The present study was conducted to compare OGTT and glycosylated hemoglobin (HBA1C) as a predictor for gestational diabetes mellitus. The patients for the Comparison between OGTT and glycosylated hemoglobin (HBA1C) as a predictor for gestational diabetes mellitus were selected from the cases admitted to Department of obstetrics and gynecology. Study Group included 150 pregnant female after 22 weeks gestation attending OPD were selected for the study. All participants underwent blood tests in their first trimester. Gestational age was confirmed on the basis of the self‐reported date of the last menstrual period or by ultrasound. Each participant’s age, number of deliveries, blood pressure, height, and weight were recorded. For these patients, simultaneous prospective assessment of HbA1c versus standard OGTT in a cohort of consecutive pregnant women were performed. Study variables i.e. age, weight, height, socioeconomic status, BMI, previous history of DM, family history of DM, HBA1C, OGTT were noted. The data was analyzed statistically using student t test, Chi‐Square test. A p‐value less than 0.05 was considered statistically significant. Out of 150 females, final diagnosis of GDM found in 17 subjects with deranged GTT which shows significant (p<0.001) relationship between GDM and GTT. In our study, result shows that HbA1C is more accurate in diagnosing GDM with accuracy of 89.04% when compared with the accuracy of OGTT OF 66.44%. OGTT being the more sensitive parameter where specificity is more with HbA1C. The area under the curves of diagnostic criteria was 0.846 for GTT, 0.836 for HBA1C. The optimal GTT level cut‐off point for predicting GDM is 155, with a sensitivity of 75.0% whereas the optimal HBA1C level cut‐off point for predicting GDM is 6.11%, with a sensitivity of 60.0.0% HbA1C has the highest specificity but OGTT has the highest sensitivity, from this we concluded that OGTT should be used as screening test in all the patients attending the antenatal OPD which should be further confirmed using HbA1C levels.
How to cite this article:
Shagun Bhatia, Palak Jain and Saumya Singh Mitra. Comparison Between OGTT and Glycosylated Hemoglobin (HbA1C) as a Predictor for Gestational Diabetes Mellitus.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.347.350
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.347.350