Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
123
Views
26
Downloads
Effects of Intravenous Injection of Magnesium Sulfate on Post Operative Analgesia in Patients Undergoing Lower Limb Orthopaedic Surgery Under Spinal Anaesthesia: A Randomised Double‐Blind Indian Study
V. Anjuna, Kiran V. Todkari and Vyankatesh S. Joshi
Page: 351-356 | Received 27 Jan 2024, Published online: 09 Mar 2024
Full Text Reference XML File PDF File
Abstract
Published evidence have shown the utility of magnesium (Mg) infusion during general anaesthesia, but the effects of magnesium sulphate (MgSO4) infusion during spinal anaesthesia have been seldom evaluated. Present study was undertaken to study the effectiveness of intravenous injection of MgSO4 on postoperative analgesia in patients undergoing lower limb orthopaedic surgery under spinal anaesthesia. A comparative, double‐blind study was conducted by department of anaesthesiology at Vilasrao Deshmukh Government Medical College Hospital in Latur city (Maharashtra state of India). Patients undergoing lower limb orthopaedic surgery (ASA I and II) under spinal anaesthesia were screened for study inclusion between January 2021 and November 2022. Group A received injection MgSO4 8mg/kg/hour in 500 ml ringer lactate intravenously; and group B received same volume of placebo (0.9%Normal saline). Sensory block and motor block assessment was done along with post‐operative pain evaluation. 30 patients were enrolled in each group. Majority patients in group A (56.67%) and group B (63.33%) were males, with comparable age and duration of surgery (p>0.05). Durations for anaesthesia, analgesia, sensory blockade and motor blockade were all significantly higher in Group A versus Group B (p<0.05). Mean VAS pain scores from 1‐12 hours post‐surgery were significantly lower in Group A versus Group B (p<0.05). Both, sensory and motor blockade were sustained to a significantly greater extent in group A between 4 hours to 8 hours post‐surgery (p<0.05). Safety was comparable between study groups (p>0.05). Duration of sensory and motor blockade was significantly increased by intravenous MgSO4 in patients undergoing lower limb orthopaedic surgery under spinal anaesthesia. The requirement of rescue analgesia was also reduced with MgSO4, with comparable safety to placebo.
How to cite this article:
V. Anjuna, Kiran V. Todkari and Vyankatesh S. Joshi. Effects of Intravenous Injection of Magnesium Sulfate on Post Operative Analgesia in Patients Undergoing Lower Limb Orthopaedic Surgery Under Spinal Anaesthesia: A Randomised Double‐Blind Indian Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.351.356
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.351.356