Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
Abstract
Chronic otitis media (COM) represents a significant health concern, manifested by persistent fluid collection behind the tympanic membrane without acute infection symptoms. This research aimed to explore the roles of oxidative stress and the anti oxidative defense mechanism in patients with COM, distinguishing between those with and without cholesteatoma. This investigation encompassed 100 individuals diagnosed with COM, divided into two groups depending on the presence of cholesteatoma: 50 patients with cholesteatoma and 50 patients without cholesteatoma. Serum and diseased ear tissue samples were collected preoperatively and audiometric evaluations were conducted for all participants. The study measured serum levels of oxidative stress markers, including malondialdehyde (MDA) and antioxidant enzymes such as super oxide dismutase (SOD), catalase (CAT) and glutathione per oxidate (GPx), along with vitamin A, employing HPLC techniques. In this study, participants encompassed a gender‐inclusive cohort ranging in age from 20‐40 years. The comparative analysis of baseline characteristics revealed no significant differences between the two study groups. Notably, markers of oxidative stress and vitamin A concentrations were found to be substantially elevated in the group diagnosed without cholesteatoma. Oxidative stress, induced by ROS, is crucial in COM development. Serum markers can effectively assess oxidative stress in COM, yet may not fully indicate disease severity. Vitamin A's impact on COM incidence is indirect, but its antioxidant ability could be vital in managing the disease's pathophysiology. A larger, detailed study on Vitamin A intake is essential to clarify its role.
How to cite this article:
Shashank Tyagi, Dharmveer Sharma, Sanket Shah and Vidushee Upadhyay. Assessment of Oxidative Mechanisms and Vitamin A Among Patients with Chronic Otitis Media.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.463.466
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.463.466