Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Hepatitis A is a transient liver ailment that can lead to significant morbidity, especially in pediatric populations from economically disadvantaged backgrounds in certain regions of the world. This disease is known to induce notable changes in liver function parameters. The primary goal of this study was to investigate the biochemical alterations observed in viral hepatitis A among pediatric patients upon admission to healthcare facilities. This observational study, of a cross‐sectional nature enrolled 123 newly diagnosed hepatitis A patients. Blood samples were collected to measure serum levels of total and direct bilirubin, alanine aminotransferase (ALT), aspartame aminotransferase (AST), alkaline phosphatase, total protein and albumin. The collected data underwent statistical analysis using appropriate methods. Majority patients were male. Notably, majority of patients exhibited serum direct bilirubin levels ranging from 0.45 and 2.1 mg/dl with only five patients exceeding 4.2 mg/dl. A significant increase (more than 5‐fold) in ALT and AST levels was observed in majority of cases. Elevated ALT and AST levels exceeding 1000 U/L were also recorded in few cases. Alkaline phosphatase levels were elevated in 24.39% of cases, while 13.82% of patients displayed hypoproteinemia. Additionally, 11 cases presented with elevated blood urea levels and 1 case showed an elevated creatinine level. The hepatitis A virus caused significant alterations in various body parameters, contributing to a substantial burden of mortality and morbidity. Given its heightened prevalence in underdeveloped communities, preventing the disease could potentially save numerous lives globally.
How to cite this article:
Shashank Tyagi, Sangeeta Dudve, Shubhangam Sharma and Shiv Singh Manjhi. Evaluation of Biochemical Parameters in Pediatric Patients with Acute Viral Hepatitis: A Cross Sectional Study.
DOI: https://doi.org/10.36478/10.59218/makrjms.2024.4.508.511
URL: https://www.makhillpublications.co/view-article/1815-9346/10.59218/makrjms.2024.4.508.511